EMD 518A Principles of Infectious Diseases I

EMD 518A Principles of Infectious Diseases I
Homework I

1. Short answer for each:
A. Define R0- What two assumptions do we generally make when estimating R0?
B. What is one formula used to estimate R0? Describe/define each parameter as part of your answer.
C. Which parameter(s) making up R0 may play the most critical role in maintaining transmission of (explain why):
i. Measles virus
ii. Herpesvirus type 1
iii Plasmodium falciparum (malaria)
D. How might R0 change for measles in a rural, as opposed to urban, population?
E. What is the estimated percentage of a population you would have to vaccinate for pathogen X if R0 =0.85, 3, 5, and 10?

2. A deadly pandemic is going to sweep the globe in 2017 and it isn’t influenza. While this novel pathogen has never been “seen” before, it has specific traits that make it highly successful. Look into your crystal ball to predict and describe this novel agent and the next pandemic. Suggested length 1-2 pages. In your description of the next pandemic include a discussion of the following:
A. Place of origin

B. Type of pathogen (e.g., virus, bacteria, eukaryotic parasite)
C. Time frame/rapidity and extent of spread
D. Target populations with highest incidence of disease
E. Estimates of morbidity and mortality that include total number of people infected
F. Types of control measures needed to contain the pandemic