toxicity

Essay
Provide an overview of the toxicity of the following workplace air contaminants:
??1 Manganese dust and fume? 2. Sodium cyanide

* For each of the two air contaminants, discuss:
??1. Routes of exposure? (4marks)
Excellent understanding of multiple sources of exposure

2. Applicable Occupational Exposure limits (OELs / PELs) (2marks)
OEL identified, reference to source. solid argument on choice of OEL

?3. Toxico-kinetics (10marks)
Outline of how each substance can gain entry to the body, how & where its distributed, pathways for biotransformation. If it is metabolized, sites of accumulation /
storage if appropriate, and pathways for its elimination from the body

?4. Toxico-dynamics?? (10marks)
Description of how each substance (or its metabolite) can interact with cells and tissues to cause harm (mechanism of harm).

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